Theory that a 74,000-year-old super-eruption nearly drove humanity extinct, leaving genetic bottlenecks visible today. Increasingly contested in recent years.
From Wikipedia
The Toba eruption was a large eruption that occurred around 74,000 years ago, during the Late Pleistocene, at the site of present-day Lake Toba, in Sumatra, Indonesia. It was the last in a series of at least four caldera-forming eruptions there, the earlier known caldera having formed about 1.2 million years ago. This, the last eruption, had an estimated volcanic explosivity index of 8, making it the largest known explosive volcanic eruption in the Quaternary, and one of the largest known explosive eruptions in the Earth's history.